Endocrine Abstracts

Sex hormones act both as endocrine signals as well as local paracrine or autocrine factors in the nervous system. In addition to target to classical endocrine and reproductive brain areas, sex hormones and its metabolites affect learning and cognition and regulate the development and plasticity of brain regions that are not directly related to reproduction. Estrogen and progesterone exert neuroprotective effects in the central nervous system and may affect the onset and progre...

Introduction: The prevalence of metabolic syndrome (MetS) is increasing in patients with HIV infection on highly active antiretroviral therapy (HAART). Additionally, HCV coinfection is common among HIV patients in our area. It is widely known MetS impacts on the liver in different ways but relationship between both MetS and liver function is few studied in HIV/HVC co-infected population.Methods/design: Cross-sectional study including 35 HIV/HVC co-infect...

Introduction: The use of glucagon like peptide 1 analogues (GLP1a) for the treatment of type 2 diabetes mellitus (T2DM) is growing. After a decade-long effort to improve the pharmacokinetics of GLP1, a number of GLP1a are currently available on the market. With a view to identifying patient characteristics that could influence physicians’ prescription of different GLP1a we carried out this observational study in routine clinical practice conditions. Outcomes after add-on ...

Introduction: Multiple studies have evaluated the efficacy of SGLT-2 inhibitors (SGLT2i) and GLP-1 receptor agonists (GLP1ra) in patients with type 2 diabetes mellitus (T2DM). However, their efficacy in clinical practice is less known in patients receiving insulin and few are the studies that compare use of SGLT2i vs GLP1ra as add-on therapy to insulin. This study aims to assess clinical efficacy of both treatments in a cohort of patients with T2DM on insulin and poor glycemic...

Introduction: Predictors for therapeutical response of SGLT-2 inhibitors (SGLT2i) is scarcely studied. The aim of the study was to retrospectively analyse the clinical parameters that contribute to the therapeutic outcomes of SGLT2i.Methods/design: We enrolled 75 patients with type 2 diabetes mellitus (T2DM), treated with SGLT2i for longer than three months. The patients were divided into two groups: good responders (if HbA1c-lowering effects were &#8805...

Introduction: Association between liver fibrosis and body mass index (BMI) is well known in HIV/HCV patients, is linked to worse lipid profile and is widely used to predict liver fibrosis in this population. Nevertheless, recent studies show a stronger link between dyslipidemia and liver stiffness with visceral adiposity index (VAI) in general population. The main aim of this study was to investigate the accuracy of VAI and BMI as predictors for liver fibrosis and dyslipidemia...

Background: The gradual increase in the detection rate of adrenal incidentalomas makes them a common clinical problem. The vast majority of them are benign adrenocortical adenomas. Nevertheless every patient with adrenal incidentaloma requires performing number of tests to exclude pheochromocytoma, autonomous cortisol secretion, adrenal carcinoma and primary hyperaldosteronism. Evaluation of whether adrenal incidentalomas are malignant or functional and continuing patient foll...

Background: Cardiovascular (CVS) risk factors could be present in patients with mild adrenal autonomous cortisol secretion (MACS), which could account for up to 50% of patients with adrenal adenomas. However, the most frequent CVS risk factors in MACS have not been established.Objective: The aim of the present study was to analyse the difference in CVS risk factors in patients with MACS in comparison to those with non-functioning adrenal tumour (NFAT).</...

Introduction: Reoperation due to recurrent or persistent thyroid cancer (TC) poses a real challenge to a surgeon who must properly estimate the benefit risk-ratio. Radioguided occult lesion localization (ROLL) technique may facilitate the localization and sufficient and safe removal of nonpalpable TC relapse.Aim: To analyze the efficacy of the ROLL technique in reoperation of TC relapse.Material and methods: A retrospective study o...

Introduction: Several investigations proved the presence of receptors for androgens, estrogens and progesterone in vocal folds. The most common endocrine disorder causing alterations in the aforementioned hormones concentrations is polycystic ovary syndrome (PCOS), which, according to several studies, can cause voice changes, especially deepening of its timbre. Over last few years, vocal changes accompanying many different disorders have been a subject of research with the use...